Cardiothoracic & vascular anesthesia
Point-of-Care Viscoelastic Hemostatic Assays in Cardiac Surgery Patients: Comparison of Thromboelastography 6S, Thromboelastometry Sigma, and Quantra
Authors' conclusion
ROTEM sigma, TEG 6S, and Quantra performed similarly for exploring platelet count or residual circulating heparin. Thromboelastography 6S presented a weaker correlation with fibrinogen Clauss.
Study context
- Population
- Adults with significant bleeding in the ICU after cardiac surgery, university hospital31 samples
- Participants
- 16 adults
- Exposure
- ROTEM sigma vs TEG 6S vs Quantra point-of-care viscoelastic assays
- Outcome
- Correlation with platelet count
Methodological detailsnonrandomized, single-centre
- Nonrandomized
- Single-centre
Main finding
As reported in the abstract
| Group | Value | P |
|---|---|---|
| ROTEM | r 0.84 (CI 0.66–0.93) | p < 0.0001 |
| Quantra | r 0.83 (CI 0.64–0.92) | p < 0.0001 |
| TEG 6S | r 0.64 (CI 0.29–0.83) | p = 0.001 |
Value
ROTEMr 0.84 (CI 0.66–0.93)
Quantrar 0.83 (CI 0.64–0.92)
TEG 6Sr 0.64 (CI 0.29–0.83)
P
ROTEMp < 0.0001
Quantrap < 0.0001
TEG 6Sp = 0.001
Observational data: associations, not effects.
Further findings
Correct identification of residual circulating heparin (anti-Xa activity >0.1)
Time to first results after test start — Quantra vs ROTEM · shorter for Quantra
P = 0.003
| Outcome | ROTEM | TEG 6S | Quantra | P value |
|---|---|---|---|---|
| Correlation with fibrinogen (Clauss assay) | 0.85 (CI 0.68–0.93) | 0.79 (CI 0.55–0.91) | 0.88 (CI 0.74–0.95) | |
| P | p < 0.0001 | p < 0.0001 | p < 0.0001 | |
| Time to first results after test startQuantra vs TEG 6S · shorter for Quantra | P < 0.0001 |
- Correct identification of residual circulating heparin (anti-Xa activity >0.1) — No difference between devices
- p = 0.3
Original publication
Point-of-Care Viscoelastic Hemostatic Assays in Cardiac Surgery Patients: Comparison of Thromboelastography 6S, Thromboelastometry Sigma, and Quantra. J Cardiothorac Vasc Anesth. Published 22 February 2023. doi:10.
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