Cardiothoracic & vascular anesthesia
Cost-utility of point-of-care viscoelastic hemostatic assays in the management of bleeding during cardiac surgery: A single-blinded prospective multicenter stepped wedge cluster randomized trial in French context
Primary result · Utility and ICURResult — go to the resultAdjusted difference −0.01 95% CI −0.09 to 0.07Authors' conclusion
The ICUR did not suggest that VHA was cost-effective in cardiac surgery patients with ongoing bleeding, compared with standard tests.
Study context
- Population
- Adults undergoing elective or urgent cardiac surgery with ongoing bleeding, 16 French academic centres, 01/2017 to 02/20201,044 (95.3%) analysed
- Participants
- 1,095 adults
- Comparison
- Viscoelastic hemostatic assay (VHA)-guided algorithm vs standard hemostasis tests for transfusion
- Primary endpoint
- Incremental cost-utility ratio (ICUR)
- Follow-up
- 1 year
Methodological detailssingle-blinded (patient blinded), prospective, multicentre, cost-utility analysis
- Single-blinded (patient blinded)
- Prospective
- Multicentre
- Cost-utility analysis
Primary result
Utility and ICUR
Adjusted difference
−0.01
95% CI −0.09 to 0.07
By group
VHA
0.60
mean · ± 0.30
Control
0.61
mean · ± 0.30
VHA vs Control
adjusted difference −0.01 (95% CI −0.09 to 0.07)
As reported in the abstract
Secondary outcomes
Plasma transfusion
P < 0.0001
Platelet transfusion
P = 0.0002
Fibrinogen administration
P = 0.002
In-hospital LOS
P = 0.02
| Outcome | VHA | Control | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Mortality · 1 year | 12.0% | 10.9% | 1.69 (0.98–2.89) | P = 0.06 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Cost-utility of point-of-care viscoelastic hemostatic assays in the management of bleeding during cardiac surgery: A single-blinded prospective multicenter stepped wedge cluster randomized trial in French context. Anaesth Crit Care Pain Med. Published 20 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →