Definitions, rates and associated mortality of intensive care unit (ICU)-acquired pneumonia: A multicenter cohort study
Authors' conclusion
Rates of ICU-acquired pneumonia vary by definition and are associated with differential increased risk of death.
Study context
- Population
- Mechanically ventilated adults in an international RCT of probiotics
- Participants
- 2,650 participants
- Comparison
- ICU-acquired pneumonia according to 7 definitions
- Primary endpoint
- VAP (ventilation ≥2 days, new, progressive or persistent infiltrate plus 2 of: temperature > 38 °C or < 36 °C; leukopenia or leukocytosis; purulent sputum)
Methodological detailsmulticentre, blinded adjudication, Each clinically suspected pneumonia adjudicated by two physicians blinded to allocation and center
- Multicentre
- Blinded adjudication
- Each clinically suspected pneumonia adjudicated by two physicians blinded to allocation and center
Primary result
As reported in the abstract
Frequency of ICU-acquired pneumonia
Further findings
Association with hospital mortality
| HR (CI) | ||
|---|---|---|
| VAP | 1.31 (1.08–1.60) | |
| ISF | 1.32 (1.09,1.60) | |
| CPIS | 1.30 (1.08,1.58) | |
| ACCP | 1.22 (1.00,1.47) | |
| 0.512Hazard ratio (log scale) |
Original publication
Definitions, rates and associated mortality of ICU-acquired pneumonia: A multicenter cohort study. J Crit Care. Published 3 March 2023. doi:10.
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