ICU sedation, delirium & recovery
Derivation and validation of a prediction rule for sedative-associated delirium during acute respiratory failure requiring mechanical ventilation
Authors' conclusion
Risk for sedative-associated delirium during acute respiratory failure requiring mechanical ventilation can be quantified using a simple, transparent model, which can now be validated in a prospective study.
Study context
- Population
- Mechanically ventilated ICU patients with septic or cardiogenic shock, acute respiratory failure, or both; five US hospitalsparent cohort 1040
- Participants
- 836 vs 340
- Comparison
- Derivation vs External validation
- Derivationn = 836
- External validationn = 340
- Outcome
- Sedative-associated delirium (model discrimination, AUROC)
Methodological detailsbackward stepwise logistic regression, internal validation (hundredfold bootstrapping), external validation in a separate prospective cohort, multicentre
- Backward stepwise logistic regression
- Internal validation (hundredfold bootstrapping)
- External validation in a separate prospective cohort
- Multicentre
Performance
As reported in the abstract
Discrimination for sedative-associated delirium (AUROC)
| Test or model | Area under the receiver-operator curve (AUROC) |
|---|---|
| External validation | 0.70 |
External validation
Area under the receiver-operator curve (AUROC)0.70
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Derivation and validation of a prediction rule for sedative-associated delirium during acute respiratory failure requiring mechanical ventilation. J Crit Care. Published 31 December 2025. doi:10.
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