Pediatric anesthesia & critical care

Description of the Properties of an Herbal Admixture (BabySed) During Trans‐Thoracic Echocardiography in Children Under Six Years Old, and Comparison to Chloral Hydrate

Paediatr AnaesthPublished Randomised controlled trial

Primary result · Ramsay sedation score ≥ 4Result — go to the resultOdds ratio 0.31 95% CI 0.03–3.16

Authors' conclusion

The results of our study suggest that an herbal mixture can be effectively used for procedural sedation during echocardiography in children.

Study context

Population
Children under six years old undergoing trans-thoracic echocardiography
Participants
70 participants
Comparison
Herbal mixture vs chloral hydrate for sedation
Primary endpoint
Adequate sedation (Ramsay sedation score ≥ 4)
Methodological detailsConducted April 2022 to July 2022
  • Conducted April 2022 to July 2022

Primary result

Ramsay sedation score ≥ 4

Odds ratio

0.31

95% CI 0.03–3.16

p:0.32

By group

Herbal mixture vs Chloral hydrate
OR 0.31 (95% CI 0.03–3.16); p:0.32

As reported in the abstract

Further findings

Shorter onset of action with chloral hydrate
P = 0.029
Longer duration of action with chloral hydrate
P < 0.001

Safety

Higher adverse effects with chloral hydrate
P < 0.001
No oxygen desaturation or BP fluctuations during procedure or recovery

Original publication

Description of the Properties of an Herbal Admixture (BabySed) During Trans‐Thoracic Echocardiography in Children Under Six Years Old, and Comparison to Chloral Hydrate. Paediatr Anaesth. Published 4 August 2025. doi:10.1111/pan.70030

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