Cardiac arrest & resuscitation
Design projections for prospective studies evaluating the clinical effectiveness of cardiac arrest detection technologies
Authors' conclusion
A prospective trial of OHCA detection technologies will require large recruitment targets. Subgroups with the highest estimated treatment effect are not those with the highest incidence.
Study context
- Population
- Emergency Medical Services (EMS)-treated and EMS-untreated OHCA cases in the British Columbia Cardiac Arrest Registry (2019–2020) who may have benefitted from cardiac arrest detectionpopulation-at-risk 9,739,356
- Participants
- 11,382 participants
- Outcome
- Required sample sizes for potential primary trial outcomes (survival to hospital discharge, initial shockable rhythm, EMS treatment) by age–sex stratum
Methodological detailstrial design projection, British Columbia Cardiac Arrest Registry, stratified by age and sex
- Trial design projection
- British Columbia Cardiac Arrest Registry
- Stratified by age and sex
Main finding
As reported in the abstract
Required trial sample size, most efficient subgroup
Survival outcome: most efficient subgroup Males aged 56-65, total needed
171,676
EMS treatment outcome: most efficient subgroup Males over 65, total needed
7,608
Initial shockable rhythm outcome: most efficient subgroup Males over 65, total needed
66,962
Observational data: associations, not effects.
Further findings
Strata-specific incidence
- Range across age–sex strata
- 18.3 per 100,000 to 395 per 100,000
Original publication
Design projections for prospective studies evaluating the clinical effectiveness of cardiac arrest detection technologies. Resuscitation. Published 13 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →