Pediatric anesthesia & critical care
Determination of the ED90 of Dexmedetomidine Infusion to Prevent Emergence Agitation in Children Undergoing Dental Rehabilitation With Sevoflurane Anesthesia: A Biased-Coin Up-and-Down Sequential Allocation Trial
Authors' conclusion
The ED90 for continuous intraoperative DEX infusion for EA prevention in pediatric patients receiving dental treatment under sevoflurane anesthesia was 0.74 µg/kg/h (95% CI, 0.67-1.05 µg/kg/h).
Study context
- Population
- Children aged 3 to 7 years undergoing dental treatment under sevoflurane anesthesia
- Participants
- 45 children
- Outcome
- ED90 of continuous DEX infusion for emergence agitation (EA) prevention (success or failure of EA-preventing dose)
Methodological detailsbiased-coin up-and-down sequential allocation, biased-coin design
- Biased-coin up-and-down sequential allocation
- Biased-coin design
Main finding
As reported in the abstract
ED90 of DEX for preventing EA
Dexmedetomidine (DEX)
0.74
ED90 · 95% CI 0.67–1.05 · µg/kg/h
Further findings
Duration of surgery
- Duration of surgery (mean ± SD)
- 113 ± 30 minutes
Time to extubation, time to emergence, recovery time
- Time to extubation (mean ± SD)
- 5 ± 2 minutes
- Time to emergence (mean ± SD)
- 27 ± 9 minutes
- Recovery time (mean ± SD)
- 39 ± 7 minutes
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Determination of the ED90 of Dexmedetomidine Infusion to Prevent Emergence Agitation in Children Undergoing Dental Rehabilitation With Sevoflurane Anesthesia: A Biased-Coin Up-and-Down Sequential Allocation Trial. Anesth Analg. Published 21 July 2024. doi:10.
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