Paediatric anaesthesia & critical care
Up‐and‐Down Sequential Allocation Study Comparing the Median Effective Dose of Remimazolam Versus Propofol for Inducing Unconsciousness in Pediatric Patients
Authors' conclusion
Using a sequential up-and-down design, this study provides the first determination of the ED50 (0.17 mg/kg) of a single intravenous bolus of remimazolam for inducing loss of consciousness in pediatric patients aged 2-14 years.
Study context
- Population
- Children aged 2 to 14 years undergoing elective surgery
- Participants
- fifty children
- Comparison
- Remimazolam vs propofol for anaesthesia induction
- Primary endpoint
- ED50 and ED95 of each drug for loss of consciousness during induction
Methodological detailsprospective, Dixon up-and-down sequential design, two separate, parallel dose-finding studies
- Prospective
- Dixon up-and-down sequential design
- Two separate, parallel dose-finding studies
Primary result
As reported in the abstract
ED50 and ED95 for loss of consciousness
| Group | Value | ED95 |
|---|---|---|
| Remimazolam | ED50 0.17 (95% CI 0.16–0.19) mg/kg | 0.26 mg/kg (95% CI 0.23-0.29) |
Remimazolam
ValueED50 0.17 (95% CI 0.16–0.19) mg/kg
ED950.26 mg/kg (95% CI 0.23-0.29)
Secondary outcomes
BIS values · within 5 min
- Both drugs effectively reduced BIS values, with a significant group-time interaction
Heart rate · within 5 min
- Heart rate more stable with remimazolam
Safety
Respiratory depression, hypotension, other serious adverse events · within 5 min after drug administration
- No respiratory depression, hypotension, or other serious adverse events observed in either group
Original publication
Up‐and‐Down Sequential Allocation Study Comparing the Median Effective Dose of Remimazolam Versus Propofol for Inducing Unconsciousness in Pediatric Patients. Paediatr Anaesth. Published 2 September 2026. doi:10.
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