Perioperative medicine & outcomes

Developing and validating a machine learning ensemble model to predict postoperative delirium in a cohort of high-risk surgical patients: A secondary cohort analysis

Eur J AnaesthesiolPublished Secondary analysis of a prospective cohort of high-risk surgical patients

Authors' conclusion

A predictive model composed of three indicative readily available features performed better than those with numerous perioperative features, pointing to its feasibility as a prognostic tool for POD.

Study context

Population
Inpatients with all-cause postoperative 30-day mortality risk >5% (ExCare Model), 800-bed quaternary university teaching hospital, Southern Brazil, September 2015 to February 2020
Participants
1,453 inpatients
Comparison
52 preoperative vs 60 postoperative vs Three features
Primary endpoint
Incidence of POD (Confusion Assessment Method); model performance compared by AUC
Follow-up
Up to 7 days postoperatively
Methodological detailsmachine-learning ensemble prediction model, nested cross-validation, single-centre
  • Machine-learning ensemble prediction model
  • Nested cross-validation
  • Single-centre

Primary result

As reported in the abstract

POD incidence and model AUC

Cumulative incidence of delirium

117

Absolute risk of postoperative delirium (POD) per 100 patients

8.05

Original publication

Developing and validating a machine learning ensemble model to predict postoperative delirium in a cohort of high-risk surgical patients: A secondary cohort analysis. Eur J Anaesthesiol. Published 1 March 2023. doi:10.1097/eja.0000000000001811

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