Pediatric anesthesia & critical care
Development and validation of a nomogram to predict the risk of sepsis-associated encephalopathy for septic patients in pediatric intensive care unit (PICU): a multicenter retrospective cohort study
Authors' conclusion
The novel nomogram and online calculator showed performance in predicting the morbidity of SAE in patients with sepsis admitted to the PICU
Study context
- Population
- Patients with sepsis admitted to the PICU of three hospitals in Shandong, China, January 2017 to May 2022790 screened
- Participants
- 613 patients
- Exposure
- Training vs Validation cohort 1 vs Validation cohort 2
- Trainingn = 251
- Validation cohort 1n = 193
- Validation cohort 2n = 169
- Outcome
- Nomogram performance for predicting SAE (discrimination and calibration)
Methodological detailsprediction model development and validation, LASSO variable selection, external validation cohorts
- Prediction model development and validation
- LASSO variable selection
- External validation cohorts
Main finding
As reported in the abstract
Discrimination of the nomogram for SAE
| Group | AUC | Sensitivity | Specificity |
|---|---|---|---|
| Training | 0.82 (95% CI 0.76-0.88) | 65.6% | 88.8% |
| Validation cohort 1 | 0.80 (95% CI 0.74-0.86) | 75.0% | 74.3% |
| Validation cohort 2 | 0.81 (95% CI 0.73-0.88) | 69.1% | 83.3% |
AUC
Training0.82 (95% CI 0.76-0.88)
Validation cohort 10.80 (95% CI 0.74-0.86)
Validation cohort 20.81 (95% CI 0.73-0.88)
Sensitivity
Training65.6%
Validation cohort 175.0%
Validation cohort 269.1%
Specificity
Training88.8%
Validation cohort 174.3%
Validation cohort 283.3%
Observational data: associations, not effects.
Further findings
Incidence of sepsis-associated encephalopathy (SAE) (overall)
- Patients who developed SAE
- 237 (38.7%)
Predictors of SAE
- SAE associated with respiratory rate, blood urea nitrogen, activated partial thromboplastin time, PaCO2 and pediatric critical illness score
Original publication
Development and validation of a nomogram to predict the risk of sepsis-associated encephalopathy for septic patients in PICU: a multicenter retrospective cohort study. J Intensive Care. Published 20 February 2024. doi:10.
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