Pediatric anesthesia & critical care
Intraoperative Thromboelastography-activated Clotting Time After Weaning From Cardiopulmonary Bypass Correlates With Fibrinogen Concentration, and Its Prolongation May Predict Hypofibrinogenemia
Authors' conclusion
In pediatric patients undergoing cardiac surgery with CPB, intraoperative T-ACT measured after weaning from CPB correlated with fibrinogen concentration, and T-ACT prolongation may discriminate hypofibrinogenemia.
Study context
- Population
- Children aged <7 years scheduled for elective cardiac surgery using cardiopulmonary bypass (CPB)
- Participants
- 218 children
- Outcome
- Correlates of T-ACT after weaning from CPB and discrimination of hypofibrinogenaemia
- Follow-up
- After weaning from CPB and protamine administration
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Multivariate regression: fibrinogen level, prothrombin time and citrated functional fibrinogen MA statistically significant
- p < 0.05
- Thromboelastography-activated clotting time (T-ACT) cutoff for discriminating fibrinogen ≤150 mg/dL (ROC)
- 158.1 seconds
- AUC of T-ACT for fibrinogen ≤150 mg/dL
- 0.84; p < 0.0001
Observational data: associations, not effects.
Original publication
Intraoperative Thromboelastography-activated Clotting Time After Weaning From Cardiopulmonary Bypass Correlates With Fibrinogen Concentration, and Its Prolongation May Predict Hypofibrinogenemia. J Cardiothorac Vasc Anesth. Published 9 August 2026. doi:10.
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