Pediatric anesthesia & critical care
Heparin Dose-Response Curve for Heparin Dose Determination During Cardiopulmonary Bypass for Pediatric Cardiac Surgery: A Prospective Randomized Controlled Study
Authors' conclusion
HDR-guided heparinization reduced heparin and protamine exposure and was associated with less bleeding and transfusion, but it did not improve first-pass ACT attainment.
Study context
- Population
- Children <14 years undergoing elective cardiac surgery with cardiopulmonary bypass (CPB), tertiary care hospital in India
- Participants
- 36 vs 36
- Comparison
- Heparin dose-response (HDR) vs Controls
- HDRn = 36
- Controlsn = 36reference
- Primary endpoint
- First-pass attainment of target ACT ≥480 seconds before CPB
- Follow-up
- Before CPB
Methodological detailssingle-centre, prospective, double-blinded, non-inferiority
- Single-centre
- Prospective
- Double-blinded
- Non-inferiority
Primary result
As reported in the abstract
Target ACT ≥480 seconds achieved at first pass
P = 0.396
Further findings
Total heparin exposure
P < 0.001
Protamine use
P = 0.002
Blood loss · 24 hours
P = 0.03
Packed RBC transfusion
P = 0.04
Original publication
Heparin Dose-Response Curve for Heparin Dose Determination During Cardiopulmonary Bypass for Pediatric Cardiac Surgery: A Prospective Randomized Controlled Study. J Cardiothorac Vasc Anesth. Published 27 June 2026. doi:10.
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