Pediatric anesthesia & critical care
Single-dose Intraoperative Methadone for Pain Management in Pediatric Tonsillectomy: A Randomized Double-blind Clinical Trial
Authors' conclusion
This small initial study in children undergoing tonsillectomy found that single-dose intraoperative methadone at 0.15 mg/kg age ideal body weight was opioid-sparing compared with intermittent fentanyl.
Study context
- Population
- Children (3 to 17 yr) undergoing tonsillectomyanalysed
- Participants
- 60 children
- Comparison
- Single-dose IV methadone 0.1 or 0.15 mg/kg vs as-needed fentanyl
- Controlsn = 20reference
- Methadone 0.1 mg/kgn = 20
- Methadone 0.15 mg/kgn = 20
- Primary endpoint
- Total 7-day opioid use in oral morphine equivalents per kg
- Follow-up
- 7 days
Methodological detailsdouble-blind, parallel group, dose escalation
- Double-blind
- Parallel group
- Dose escalation
Primary result
As reported in the abstract
Total 7-day opioid use (oral morphine equivalents per kg)
Methadone 0.1 mg/kg vs Controls: P = 0.045 · Methadone 0.15 mg/kg vs Controls: P = 0.023
Secondary outcomes
PACU opioid use (oral morphine equivalents per kg) — Methadone 0.1 mg/kg vs Controls
P = 0.061
| Outcome | P value |
|---|---|
| PACU opioid use (oral morphine equivalents per kg)Methadone 0.15 mg/kg vs Controls | P = 0.021 |
Postoperative pain scores
- Not different between groups
Safety
- No serious opioid-related adverse events occurred
Original publication
Single-dose Intraoperative Methadone for Pain Management in Pediatric Tonsillectomy: A Randomized Double-blind Clinical Trial. Anesthesiology. Published 26 April 2024. doi:10.
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