Pediatric anesthesia & critical care
Population Pharmacokinetics of Single Bolus Dose Fentanyl in Obese Children
Main finding · Fentanyl concentrationResult — go to the resultDifference 0.35 ng/mL 95% CI 0.08–0.61Authors' conclusion
Our data demonstrated higher peak plasma fentanyl concentrations in obese compared to nonobese subjects.
Study context
- Population
- Children 2 to 12 years undergoing elective tonsillectomy ± adenoidectomyhalf obese
- Participants
- 30 children
- Exposure
- Obese vs nonobese children after 1 mcg/kg intravenous (IV) fentanyl bolus based on total body weight (TBW)
- Outcome
- Fentanyl plasma concentration
- Follow-up
- 5 minutes
Methodological detailsprospective, obese vs nonobese cohorts, model simulation
- Prospective
- Obese vs nonobese cohorts
- Model simulation
Main finding
Fentanyl concentration
Difference
0.35 ng/mL
95% CI 0.08–0.61
P = 0.01
By group
Obese vs Nonobese
difference 0.35 ng/mL (95% CI 0.08–0.61); P = 0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
Population PK covariates
- Fat-free mass (FFM) was a significant covariate for the central volume of distribution
Simulated peak fentanyl effect site concentration, TBW- vs FFM-based dosing in an obese child
- 1 mcg/kg dose based on TBW: approximately higher peak effect site concentration than FFM-based dosing
- 60%
- Model simulation
Original publication
Population Pharmacokinetics of Single Bolus Dose Fentanyl in Obese Children. Anesth Analg. Published 15 December 2023. doi:10.
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