Pediatric anesthesia & critical care
Dexmedetomidine Versus Midazolam for Propofol Sparing in Procedural Sedation of Children With Leukemia: A Consecutive Case Series
Authors' conclusion
Dexmedetomidine demonstrates superior propofol-sparing effects compared to midazolam, although it requires longer recovery times.
Study context
- Population
- Pediatric oncology patients (leukemia) undergoing procedural sedation for bone marrow aspiration and/or lumbar puncture24 patients
- Exposure
- Dexmedetomidine vs midazolam premedication combined with propofol
- DPn = 51 procedures
- MPn = 52 proceduresreference
- Outcome
- Propofol dose (propofol-sparing)
Methodological detailssingle-centre, one-year
- Single-centre
- One-year
Main finding
As reported in the abstract
Propofol dose
P < 0.001
Observational data: associations, not effects.
Further findings
Wake-up time · longer in DP
P = 0.045
Safety
Adverse events
- Very rare in both groups
Original publication
Dexmedetomidine Versus Midazolam for Propofol Sparing in Procedural Sedation of Children With Leukemia: A Consecutive Case Series. Acta Anaesthesiol Scand. Published 31 July 2025. doi:10.
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