Diagnostic performance of package insert-based screening for potential drug–drug interactions in intensive care unit (ICU) patients receiving injectable medications: a retrospective diagnostic accuracy study using Lexi-Interact as the comparator in Japan
Authors' conclusion
In ICU settings, package insert-based identification of pDDIs involving injectable drugs showed high NPV, sensitivity, and specificity relative to Lexi-Interact.
Study context
- Population
- Adult (≥18 years) ICU admissions receiving injectable medications, two ICUs of a tertiary hospital in Japan
- Participants
- 345 eligible ICU admissions
- Comparison
- Package insert-based pDDI screening vs Lexi-Interact
- Outcome
- NPV of package insert-based screening for clinically significant potential drug-drug interactions (pDDIs)
- Follow-up
- Day 2, day 5 and day before ICU discharge
Methodological detailsretrospective, single-centre, ICU admission-level cluster bootstrap analysis (10,000 resamples)
- Retrospective
- Single-centre
- ICU admission-level cluster bootstrap analysis (10,000 resamples)
Performance
As reported in the abstract
Diagnostic performance vs Lexi-Interact
| Test or model | NPV | Sensitivity | Specificity | PPV |
|---|---|---|---|---|
| Package insert | 0.98 | 0.80 | 0.91 | 0.51 |
Package insert
NPV0.98
Sensitivity0.80
Specificity0.91
PPV0.51
Further findings
Interactions identified only by Lexi-Interact
- Predominantly category C, with only one category D interaction
- No category X interactions
Robustness (ICU admission-level cluster bootstrap, 10,000 resamples)
- Bootstrap analysis confirmed stable estimates of diagnostic performance
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Diagnostic performance of package insert-based screening for potential drug–drug interactions in ICU patients receiving injectable medications: a retrospective diagnostic accuracy study using Lexi-Interact as the comparator in Japan. J Intensive Care. Published 16 June 2026. doi:10.
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