Pediatric anesthesia & critical care
Diastolic Blood Pressure Threshold During Pediatric Cardiopulmonary Resuscitation and Survival Outcomes: A Multicenter Validation Study*
Main finding · Survival to hospital dischargeResult — go to the resultARR for survival to discharge 1.32 CI 1.01–1.74Authors' conclusion
These validation data demonstrate that achieving mean DBP during CPR greater than 25 mm Hg for infants and greater than 30 mm Hg for older children is associated with higher rates of survival to hospital discharge, providing potential targets for DBP during CPR.
Study context
- Population
- Children ≤18 years with in-hospital cardiopulmonary resuscitation (CPR) >30 seconds and invasive blood pressure (BP) monitoring during CPR, 18 PICUs (ICU-RESUScitation trial), October 2016 to March 2020evaluable diastolic blood pressure (DBP) data, of 1,129
- Participants
- 413 children
- Exposure
- Mean DBP during CPR >25 mm Hg / >30 mm Hg vs below threshold
- Outcome
- Survival to hospital discharge
Methodological detailsmulticentre, validation study
- Multicentre
- Validation study
Main finding
As reported in the abstract
ARR for survival to discharge
1.32
CI 1.01–1.74
P = 0.03
Mean DBP greater than 25 mm Hg for infants and greater than 30 mm Hg for older children vs DBP below threshold
aRR for survival to discharge 1.32 (CI 1.01–1.74); P = 0.03
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Estimate | P value | |
|---|---|---|---|
| ROSCMean DBP greater than 25 mm Hg for infants and greater than 30 mm Hg for older children vs DBP below threshold | aRR for ROSC 1.49 (CI 1.12–1.97) | P = 0.002 | |
| Survival to hospital discharge with favorable neurologic outcomeMean DBP greater than 25 mm Hg for infants and greater than 30 mm Hg for older children vs DBP below threshold · did not reach significance | aRR for survival with favorable neurologic outcome 1.30 (CI 0.98–1.72) | P = 0.051 | |
| 0.512Ratio (log scale) |
- Return of spontaneous circulation (ROSC): Initial return of circulation 91.5% overall, 25% by ECMO
- Survival to hospital discharge with favorable neurologic outcome: Overall 55.4%; 94.6% of survivors had favorable neurologic outcomes
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Diastolic Blood Pressure Threshold During Pediatric Cardiopulmonary Resuscitation and Survival Outcomes: A Multicenter Validation Study*. Crit Care Med. Published 9 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →