Cardiac arrest & resuscitation
Identification of post-cardiac arrest blood pressure thresholds associated with outcomes in children: an ICU-Resuscitation study
Authors' conclusion
Following pediatric IHCA, subjects had higher rates of survival to hospital discharge and survival to hospital discharge with favorable neurologic outcome when BP targets above a threshold of SBP > 10th percentile for age and DBP > 50th percentile for age during the first 6 h post-arrest.
Study context
- Population
- Children with index in-hospital cardiac arrest (IHCA) events, first 24 h after return of circulation
- Participants
- 352 vs 346
- Comparison
- Lowest post-arrest systolic BP (SBP) and diastolic BP (DBP) above vs below identified thresholds
- SBP above thresholdn = 352
- DBP above thresholdn = 346
- Primary endpoint
- Survival to hospital discharge
Methodological detailsprospectively collected blood pressure (BP) data
- Prospectively collected BP data
Primary result
As reported in the abstract
ARR for survival to hospital discharge (95% CI)P value
SBP above thresholdSBP > 10th percentile; adjusted for illness category and pre-arrest hypotension
1.21(1.10–1.33)
P < 0.001DBP above thresholdDBP > 50th percentile
1.23(1.12–1.34)
P < 0.001Further findings
Survival to hospital discharge with favourable neurologic outcome
| aRR for survival with favourable neurologic outcome (95% CI) | P value | ||
|---|---|---|---|
| SBP above threshold | 1.22 (1.10–1.35) | P < 0.001 | |
| DBP above threshold | 1.27 (1.15–1.40) | P < 0.001 | |
| 0.512ARR for survival with favourable neurologic outcome (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Identification of post-cardiac arrest blood pressure thresholds associated with outcomes in children: an ICU-Resuscitation study. Crit Care. Published 7 October 2023. doi:10.
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