Pediatric anesthesia & critical care
Severe intracranial hemorrhage or ischemia associated with unfavorable outcomes after pediatric in-hospital cardiac arrest
Authors' conclusion
The presence of severe intracranial hemorrhage or ischemia on head CT within the first 7 days post-IHCA was associated with unfavorable outcomes, and all patients with both died.
Study context
- Population
- Children in ICU-RESUS ICUs with return of circulation after in-hospital cardiac arrest who had head computerized tomography (CT) within 7 dayshad a CT
- Participants
- 180 children
- Exposure
- Severe hemorrhage or ischemia vs No severe hemorrhage or ischemia
- Severe hemorrhage or ischemian = 73
- Outcome
- Unfavorable neurologic outcome:
- Death
- Change in PCPC ≥1 from baseline resulting in hospital discharge PCPC 4-5
- Follow-up
- Hospital discharge
Main finding
As reported in the abstract
Severe hemorrhage or ischemia, by outcome
- Severe hemorrhage or ischemia: unfavorable vs favorable outcome 56 % vs 21 %
- p < 0.001
Observational data: associations, not effects.
Further findings
Duration of CPR
P < 0.001
eCPR
P = 0.010
Post-arrest lactate
P = 0.018
Severe hemorrhage and ischemia (both)
- All patients with both died
- 7
Original publication
Severe intracranial hemorrhage or ischemia associated with unfavorable outcomes after pediatric in-hospital cardiac arrest. Resuscitation. Published 7 November 2025. doi:10.
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