Different Gabapentin and Pregabalin Dosages for Perioperative Pain Control in Patients Undergoing Spine Surgery: A Systematic Review and Network Meta-Analysis
Authors' conclusion
These findings suggest that gabapentin 900 mg per day before spine surgery is associated with the lowest VAS pain score among all dosages. In addition, no differences in adverse events were noted among all treatments.
Study context
- Population
- Patients undergoing spine surgery
- Participants
- 1,861 patients · 27 RCTs
- Comparison
- Different dosages of gabapentin and pregabalin vs placebo
- Outcome
- Pain intensity (VAS)
Methodological detailsrandom-effects model, PRISMA, No substantial inconsistency between direct and indirect evidence for all outcomes
- Random-effects model
- PRISMA
- No substantial inconsistency between direct and indirect evidence for all outcomes
Pooled result
As reported in the abstract
VAS pain score
- Vs placebo, Visual Analog Scale (VAS) pain score lowest with gabapentin 900 mg/day, followed by gabapentin 1200, 600, 300 mg/day, pregabalin 300, 150 and 75 mg/day
Further pooled results
| Outcome | Mean difference (surface under the cumulative ranking curve) (%) (95% CI) | |
|---|---|---|
| Opioid consumptionGabapentin 900 mg/day vs Placebo · lowest opioid consumption among all dosages | −22.07 (−33.22% to −10.92%) | |
| −40−20020Difference, % (linear scale) |
Safety
Adverse events (nausea, vomiting, dizziness)
- No statistically significant difference among all treatments
Original publication
Different Gabapentin and Pregabalin Dosages for Perioperative Pain Control in Patients Undergoing Spine Surgery: A Systematic Review and Network Meta-Analysis. JAMA Netw Open. Published 1 August 2023. doi:10.
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