Efficacy of different routes of dexamethasone administration for preventing rebound pain following peripheral nerve blocks in adult surgical patients: a systematic review and network meta‐analysis
Authors' conclusion
Intravenous dexamethasone was associated with a high probability of decreasing the incidence of rebound pain following peripheral nerve block.
Study context
- Population
- Adult surgical patients receiving peripheral nerve blocks
- Participants
- 1,058 patients · 14 studies
- Comparison
- Intravenous vs perineural dexamethasone vs control
- Outcome
- Incidence of rebound pain
Methodological detailsSUCRA ranking
- SUCRA ranking
Pooled result
As reported in the abstract
Each group vs controlOdds ratio (95% CrI)
Intravenous dexamethasone298 fewer cases per 1000 people; moderate certainty; ranked highest
0.12(0.03–0.44)
Perineural dexamethasone190 fewer cases per 1000 people; low certainty
0.34(0.07–1.32)
Further pooled results
Time to onset of rebound pain
- No evidence of an effect of route of administration
Original publication
Efficacy of different routes of dexamethasone administration for preventing rebound pain following peripheral nerve blocks in adult surgical patients: a systematic review and network meta‐analysis. Anaesthesia. Published 10 February 2025. doi:10.
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