Prophylactic interventions to prevent rebound pain after peripheral nerve block in adults: a systematic review and network meta‐analysis of randomised controlled trials
Authors' conclusion
Intravenous dexamethasone was the most effective intervention for preventing rebound pain following single-injection peripheral nerve blocks.
Study context
- Population
- Adults undergoing surgery with peripheral nerve blocks
- Participants
- 2,130 adults · 24 RCTs
- Comparison
- Pharmacological prophylactic interventions vs control
- Outcome
- Incidence of rebound pain
Pooled result
As reported in the abstract
| Group | SUCRA |
|---|---|
| Intravenous dexamethasone | 0.91 |
Intravenous dexamethasone
SUCRA0.91
Further pooled results
Delay of rebound pain and time to first rescue analgesia
- Perineural dexamethasone and perineural dexmedetomidine ranked highest for delaying rebound pain and prolonging time to first rescue analgesia
Pain severity, patient satisfaction, sleep disturbance
- Reported inconsistently; could not be pooled
Original publication
Prophylactic interventions to prevent rebound pain after peripheral nerve block in adults: a systematic review and network meta‐analysis of randomised controlled trials. Anaesthesia. Published 26 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →