Comparison of intravenous versus perineural dexamethasone as a local anaesthetic adjunct for peripheral nerve blocks in the lower limb: A meta-analysis and systematic review
Pooled result · Duration of analgesiaResult — go to the resultMean difference 2.73 h 95% CI 1.07–4.38Authors' conclusion
In summary, moderate evidence supports the superiority of perineural dexamethasone over intravenous dexamethasone in prolonging the duration of analgesia. However, this difference is unlikely to be clinically relevant.
Study context
- Population
- Patients having lower-limb surgery with peripheral nerve blocks (mostly femoral, sciatic, ankle; long-acting local anaesthetic; dexamethasone mostly 8 mg)
- Participants
- 546 patients · 9 RCTs
- Comparison
- Perineural vs Intravenous
- Outcome
- Duration of analgesia
Pooled result
As reported in the abstract
Mean difference
2.73 h
95% CI 1.07–4.38
P = 0.001
By group
Perineural vs Intravenous
mean difference 2.73 h (95% CI 1.07–4.38); P = 0.001
Further pooled results
Duration of analgesia by block location, local anaesthetic type or perineural adrenaline (subgroup)
- No difference in duration between IV and perineural dexamethasone
Secondary efficacy outcomes
- No differences shown
Safety
Side effects
- No differences shown
Original publication
Comparison of intravenous versus perineural dexamethasone as a local anaesthetic adjunct for peripheral nerve blocks in the lower limb: A meta-analysis and systematic review. Eur J Anaesthesiol. Published 10 July 2024. doi:10.
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