Rebound Pain and Patient Satisfaction With Dexamethasone as an Adjunct for Peripheral Nerve Blocks. A Substudy Based on Two Randomised Clinical Trials
Authors' conclusion
Dexamethasone reduced pain after block cessation and the risk of rebound pain when compared with placebo.
Study context
- Population
- Patients undergoing osseous surgery of the lower or upper limb under PNB
- Participants
- 159 patients · 2 RCTs
- Comparison
- Dexamethasone vs placebo as PNB adjunct
- Dexamethasonen = 103
- Placebon = 56reference
- Primary endpoint
- Pain immediately after block cessation (NRS 0–10) and rebound pain (NRS ≥ 7 immediately after block cessation)
Methodological detailspooled substudy, placebo-controlled, three-arm trials, pooled data
- Pooled substudy
- Placebo-controlled
- Three-arm trials
- Pooled data
Further findings
- No association between patient satisfaction and rebound pain (ceiling effect in satisfaction measure)
Original publication
Rebound Pain and Patient Satisfaction With Dexamethasone as an Adjunct for Peripheral Nerve Blocks. A Substudy Based on Two Randomised Clinical Trials. Acta Anaesthesiol Scand. Published 23 July 2026. doi:10.
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