Effect of postoperative peripheral nerve blocks on the analgesia nociception index under propofol anesthesia: an observational study
Authors' conclusion
The increased ANI value after PNB under propofol anesthesia may be a valuable indicator for assessing PNB efficacy.
Study context
- Population
- Patients undergoing elective upper limb surgery under propofol anesthesia
- Participants
- 30 patients
- Exposure
- Analgesia nociception index (ANI) before vs after peripheral nerve blocks (PNB) under GA
- Outcome
- Change in median and maximum ANI before vs after PNB
Methodological detailsbefore-after (within-patient) comparison
- Before-after (within-patient) comparison
Main finding
As reported in the abstract
Median and maximum ANI
| Group | Value | Maximum ANI, median [IQR] |
|---|---|---|
| Pre PNB | median 53.5 (IQR 44.0–68.0) | 64.0 [56.3-79.5] |
| Post PNB | median 59.0 (IQR 47.0–78.3) | 74.5 [61.5-85.3] |
Value
Pre PNBmedian 53.5 (IQR 44.0–68.0)
Post PNBmedian 59.0 (IQR 47.0–78.3)
Maximum ANI, median [IQR]
Pre PNB64.0 [56.3-79.5]
Post PNB74.5 [61.5-85.3]
- Post PNB vs Pre PNB: P < 0.05 — median ANI; Wilcoxon signed-rank test
- Post PNB vs Pre PNB: P < 0.01 — maximum ANI
Observational data: associations, not effects.
Further findings
Median ANI, subgroup N2 ≥ 4 (n = 18) · 5 min before vs 20 min after PNB
- Median ANI significantly increased after PNB, pre vs post PNB, median [IQR]
- 48.0 [42.3-66.5] vs. 61.0 [50.0-76.5]
- P < 0.01
- Wilcoxon signed-rank test
Maximum ANI, subgroup N2 ≥ 4 (n = 18) · 5 min before vs 20 min after PNB
- Maximum ANI significantly increased after PNB, pre vs post PNB, median [IQR]
- 58.5 [50.3-75.3] vs. 76.0 [71.8-83.5]
- P < 0.01
- Wilcoxon signed-rank test
Median and maximum ANI, subgroup N2 < 4 (n = 12) · 5 min before vs 20 min after PNB
- No statistical differences pre vs post PNB
Original publication
Effect of postoperative peripheral nerve blocks on the analgesia nociception index under propofol anesthesia: an observational study. J Clin Monit Comput. Published 29 January 2025. doi:10.
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