Rebound pain prevention after peripheral nerve block: A network meta-analysis comparing intravenous, perineural dexamethasone, and control
Pooled result · Incidence of rebound painResult — go to the resultOdds ratio 0.13 95 % CI 0.07–0.23Authors' conclusion
Both IV and perineural dexamethasone are preferred over no dexamethasone for preventing rebound pain after PNBs, with IV dexamethasone being the more effective route.
Study context
- Population
- Patients undergoing peripheral nerve block for postoperative pain management
- Participants
- 561 patients · 7 RCTs
- Comparison
- Intravenously (IV) vs perineural dexamethasone vs control
- Outcome
- Incidence of rebound pain
Pooled result
As reported in the abstract
Odds ratio
0.13
95 % CI 0.07–0.23
By group
IV dexamethasone
0.92
P-score
IV dexamethasone vs Control
OR 0.13 (95 % CI 0.07–0.23)
Further pooled results
Time to first analgesic request, pain score difference, nausea/vomiting
- Favored both IV and perineural dexamethasone over control
Original publication
Rebound pain prevention after peripheral nerve block: A network meta-analysis comparing intravenous, perineural dexamethasone, and control. J Clin Anesth. Published 24 October 2024. doi:10.
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