Prophylactic dexamethasone for rebound pain after peripheral nerve block in adult surgical patients: systematic review, meta-analysis, and trial sequential analysis of randomised controlled trials
Pooled resultResult — go to the resultOdds ratio 0.16 95% CI 0.10–0.27Authors' conclusion
Current evidence suggests that both intravenous and perineural dexamethasone reduce the incidence of rebound pain after a peripheral nerve block provided for postoperative analgesia.
Study context
- Population
- Adults undergoing surgery with a peripheral nerve block
- Participants
- 574 adults · 7 randomised controlled trials (RCTs)
- Comparison
- Prophylactic dexamethasone vs control
- Outcome
- Incidence of rebound pain
Methodological detailstrial sequential analysis, subgroup analysis by route of administration
- Trial sequential analysis
- Subgroup analysis by route of administration
Pooled result
As reported in the abstract
Odds ratio
0.16
95% CI 0.10–0.27
P = 0.00
Dexamethasone vs Control
OR 0.16 (95% CI 0.10–0.27); P = 0.00
Further pooled results
Incidence of rebound pain by route of administration (subgroup)
- Both intravenous and perineural administration associated with a significant reduction in rebound pain incidence
Original publication
Prophylactic dexamethasone for rebound pain after peripheral nerve block in adult surgical patients: systematic review, meta-analysis, and trial sequential analysis of randomised controlled trials. Br J Anaesth. Published 26 October 2023. doi:10.
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