Pediatric anesthesia & critical care
Differentiating Lung From Chest Wall Mechanics Is Difficult Without Esophageal Manometry in Children With Acute Respiratory Distress Syndrome
Authors' conclusion
In PARDS, C RS is more strongly tied to C l than C CW . While E L /E RS is not easily predictable from clinical variables, when C RS is low, E L /E RS is generally high.
Study context
- Population
- Mechanically ventilated children with pediatric acute respiratory distress syndrome (PARDS) in a quaternary PICU750 patient days
- Participants
- 207 participants
Methodological detailsesophageal manometry monitoring, single-centre quaternary PICU
- Esophageal manometry monitoring
- Single-centre quaternary PICU
Primary result
As reported in the abstract
Correlation of E L /E RS with C RS (r)
−0.26
Lower C RS associated with high (> 0.9) E L /E RS, OR
0.70
95% CI 0.54–0.86; p = 0.002; AUC 0.73
Higher C RS associated with low (< 0.7) E L /E RS, OR
1.14
95% CI 1.02–1.28; p = 0.017; AUC 0.60
Further findings
Correlation of C RS with C l and C CW
- C RS vs C l (r; p < 0.001)
- 0.94
- C RS vs C CW (r; p < 0.001)
- 0.53
Independent predictors of C CW and C l (multivariable)
- Higher C RS, younger age and peripheral neuromuscular disease associated with higher C CW; higher C RS the only variable associated with higher C l (all p < 0.01)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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