Respiratory failure & ventilation
Discomfort of noninvasive ventilation, high flow nasal cannula oxygen, and conventional oxygen implemented after extubation in non-COPD patients
Authors' conclusion
Noninvasive ventilation was associated with a significant and persisting discomfort whereas high flow nasal cannula oxygen-induced discomfort remained limited. After 48 h, discomfort resulting from high flow nasal cannula oxygen and conventional oxygen therapy was similar and negligible.
Study context
- Population
- Non-COPD patients after extubation, at high and low risk of postextubation respiratory failure264 self-evaluated · at high 127 · low 179
- Participants
- 306 patients
- Exposure
- NIV alternating with HFNO or conventional oxygen therapy after extubation
- Outcome
- Discomfort of the interface (self-evaluated) and of the respiratory support (nurse-evaluated), 10-cm VAS
- Follow-up
- 6, 24 and 48 h after extubation
Methodological detailssecondary evaluation of post-extubation respiratory supports
- Secondary evaluation of post-extubation respiratory supports
Main finding
As reported in the abstract
Discomfort (10-cm VAS)
- Facial mask: significant and persisting self-evaluated discomfort
- Nasal prongs and oxygen mask less uncomfortable, with progressive reduction of discomfort with time
- HFNO alternating with NIV: significant and persisting nurse-reported discomfort
- Conventional oxygen therapy significantly less uncomfortable
Observational data: associations, not effects.
Further findings
Discomfort by risk of extubation failure (subgroup)
- Degree of discomfort not different in patients at high and low risk of extubation failure
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Discomfort of noninvasive ventilation, high flow nasal cannula oxygen, and conventional oxygen implemented after extubation in non-COPD patients. Crit Care. Published 31 May 2026. doi:10.
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