Discrepancies Between Point of Care and Central Laboratory Sodium and Potassium Measurements in ICU: Analytical Biases and Physician Awareness
Authors' conclusion
IP and DP were not interchangeable, each exhibiting distinct strengths and limitations.
Study context
- Population
- ICU population, tertiary hospital
- Participants
- 501 paired measurements
- Exposure
- Indirect potentiometry (IP) vs direct potentiometry (DP)
- Outcome
- Agreement between IP and DP
Methodological detailspaired measurements, single-centre (tertiary hospital)
- Paired measurements
- Single-centre (tertiary hospital)
Main finding
As reported in the abstract
Lin's concordance correlation coefficient, Na+ (moderate agreement)
0.90
Lin's concordance correlation coefficient, K+ (moderate agreement)
0.93
95% limit of agreement for Na+ (mmol/L)
10.48
Discrepancy in classification (within, below, or above normal range), Na+ and K+
≈10%
Observational data: associations, not effects.
Further findings
Physician survey (103 responding physicians)
- Aware of analytical bias in Na+ by IP
- 31.1%
- Considered K+ by DP as reliable or more reliable than IP
- 45.6%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Discrepancies Between Point of Care and Central Laboratory Sodium and Potassium Measurements in ICU: Analytical Biases and Physician Awareness. Crit Care Med. Published 13 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →