Hemodynamics, fluids & transfusion
Does the age of packed red blood cells, donor sex or sex mismatch affect the sublingual microcirculation in critically ill intensive care unit patients? A secondary interpretation of a retrospective analysis
Authors' conclusion
We detected no significant effect of pRBC on microcirculation.
Study context
- Population
- Critically ill intensive care unit (ICU) patients transfused packed red blood cells (pRBC) (Ba2MiTraL study on sublingual microcirculatory flow)
- Participants
- 54 patients
- Comparison
- Fresh vs medium vs old pRBC
- Primary endpoint
- Change from pre- to post-transfusion proportion of perfused vessels (∆PPV)
Methodological detailsretrospective
- Retrospective
Primary result
As reported in the abstract
∆PPV
Fresh
+ 8.8%
Mean · IQR - 0.5 to 22.5
Medium
5.5%
Mean · IQR 0.1–10.1
Old
+ 4.7%
Mean · IQR - 2.1 to 6.5
- No overall significant correlation between pRBC age and ∆PPV (regression models)
- P = 0.2
Further findings
| Outcome | Fresh | Medium | Old |
|---|---|---|---|
| Change in microcirculatory flow index (MFI) | + 0.22 (IQR - 0.1 to 0.6) | + 0.22 (IQR 0.0–0.3) | + 0.06 (IQR - 0.1 to 0.3) |
Lower ∆PPV and older blood vs Sequential Organ Failure Assessment (SOFA) score on ICU admission
- Lower ∆PPV and transfusion of older blood correlated with higher SOFA score on ICU admission
- P = 0.01
Donor or recipient sex
- Donor or recipient sex had no influence
Original publication
Does the age of packed red blood cells, donor sex or sex mismatch affect the sublingual microcirculation in critically ill intensive care unit patients? A secondary interpretation of a retrospective analysis. J Clin Monit Comput. Published 3 June 2022. doi:10.
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