Pediatric anesthesia & critical care
Does Celecoxib Prescription for Pain Management Affect Post-tonsillectomy Hemorrhage Requiring Surgery? A Retrospective Observational Cohort Study
Main finding · Post-tonsillectomy hemorrhage requiring surgeryResult — go to the resultOdds ratio 1.4 95% CI 0.85–2.31Authors' conclusion
Celecoxib does not significantly increase the odds of post-tonsillectomy hemorrhage requiring surgery, after adjusting for covariates.
Study context
- Population
- Children <18 yr undergoing tonsillectomy (or adenotonsillectomy), Children's Hospital of Eastern Ontario, January 2007 to December 2017complete data
- Participants
- 5,846 children
- Exposure
- Celecoxib prescription vs no celecoxib prescription after tonsillectomy
- Celecoxibn = 1,548
- No celecoxibn = 3,448reference
- Outcome
- Proportion of patients with post-tonsillectomy hemorrhage requiring surgery
Methodological detailssingle-centre, inverse probability of treatment weighting (propensity scores), generalized estimating equations (clustering by surgeon)
- Single-centre
- Inverse probability of treatment weighting (propensity scores)
- Generalized estimating equations (clustering by surgeon)
Main finding
Post-tonsillectomy hemorrhage requiring surgery
Odds ratio
1.4
95% CI 0.85–2.31
P = 0.20
Events by group
Celecoxib vs No celecoxib
OR 1.4 (95% CI 0.85–2.31); P = 0.20
As reported in the abstract
Observational data: associations, not effects.
Original publication
Does Celecoxib Prescription for Pain Management Affect Post-tonsillectomy Hemorrhage Requiring Surgery? A Retrospective Observational Cohort Study. Anesthesiology. Published 29 April 2024. doi:10.
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