Pediatric anesthesia & critical care
Does heart rate variability using the Newborn Infant Parasympathetic Evaluation index identify postsurgical pain levels and emergence delirium in toddlers? A prospective observational study
Authors' conclusion
The NIPE index can identify moderate and severe postoperative pain after adenotonsillectomy but not emergence delirium in children aged three years and younger.
Study context
- Population
- Children aged ≤3 years undergoing elective adenotonsillectomy, tonsillectomy or adenoidectomy
- Participants
- 69 children
- Exposure
- Newborn Infant Parasympathetic Evaluation (NIPE) index by pain severity and emergence delirium in postanesthesia care unit (PACU)
- Outcome
- Relationship between postoperative NIPE index and postoperative pain severity (FLACC) in PACU
Main finding
As reported in the abstract
NIPE index in PACU by pain severity
Moderate pain
50
mean · SD 12
Severe pain
49
mean · SD 14
No/mild pain
64
mean · SD 13
Each group vs No/mild painMean difference (95% CI)P value
Moderate pain
−14(−17 to −11)
P < 0.001Severe pain
−17(−20 to −14)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | Values | Mean difference (95% CI) | P value | |
|---|---|---|---|---|
| NIPEi, pain-specific ED component (ED-II) vs no ED-II | ED-II mean 49 (SD 10) · No ED-II mean 55 (SD 13) | −6 (−11 to −2) | P = 0.009 | |
| NIPEi, emergence delirium (PAED ≥ 10) vs no ED | ED mean 54 (SD 15) · No ED mean 51 (SD 10) | 3 (−2 to 8) | P = 0.23 | |
| NIPEi, delirium-specific ED component (ED-I) vs no ED-I | ED-I mean 55 (SD 15) · No ED-I mean 51 (SD 11) | 4 (0–8) | P = 0.06 | |
| −15−10−50510Difference (linear scale) |
Original publication
Does heart rate variability using the Newborn Infant Parasympathetic Evaluation index identify postsurgical pain levels and emergence delirium in toddlers? A prospective observational study. Can J Anaesth. Published 8 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →