Cardiac arrest & resuscitation
Does extracorporeal cardiopulmonary resuscitation improve survival with favorable neurological outcome in out-of-hospital cardiac arrest? A systematic review and meta-analysis
Pooled result · Survival with favorable neurological outcomeResult — go to the resultOR for survival with favorable neurological outcome 2.35 95% CI 1.61–3.43Authors' conclusion
In this meta-analysis, E-CPR had a positive effect on survival with favorable neurological outcome and, to a smaller extent, on overall mortality in patients with refractory OHCA.
Study context
- Population
- Adults with out-of-hospital cardiac arrest (OHCA)18 studies
- Comparison
- Extracorporeal cardiopulmonary resuscitation (E-CPR) vs conventional cardiopulmonary resuscitation (C-CPR)
- Outcome
- Survival with favorable neurological outcome
- Follow-up
- Discharge or 30 days
Pooled result
As reported in the abstract
OR for survival with favorable neurological outcome
2.35
95% CI 1.61–3.43
P < 0.001
By group
E-CPR vs C-CPR
OR for survival with favorable neurological outcome 2.35 (95% CI 1.61–3.43); P < 0.001
Further pooled results
| Outcome | OR for survival (95% CI) | P value | |
|---|---|---|---|
| Overall survival · discharge or 30 daysI2 = 81%; NNT = 11 | 1.71 (1.18–2.46) | P = 0.004 | |
| 0.512OR for survival (log scale) |
Survival with favorable neurological outcome, RCTs only (sensitivity analysis)
- Results consistent when restricted to RCTs
Original publication
Does extracorporeal cardiopulmonary resuscitation improve survival with favorable neurological outcome in out-of-hospital cardiac arrest? A systematic review and meta-analysis. J Crit Care. Published 24 July 2024. doi:10.
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