Cardiac arrest & resuscitation
Long-term functional outcomes and health-related quality of life following in-hospital cardiac arrest (IHCA): A systematic review
Authors' conclusion
While many IHCA survivors achieve favourable long-term outcomes, a significant proportion experience persistent impairments.
Study context
- Population
- Adults (≥18 years) receiving conventional CPR for IHCA, with neurological, cognitive, psychological or health-related quality of life (HRQoL) outcomes at ≥ 3 months39 studies · 21 countries
- Outcome
- Long-term functional outcomes following IHCA
- Follow-up
- ≥ 3 months post-IHCA
Methodological detailsPRISMA 2020, random-intercept logistic regression, narrative synthesis, Risk of bias assessed with QUIPS tool, Searches to 14 February 2025
- PRISMA 2020
- Random-intercept logistic regression
- Narrative synthesis
- Risk of bias assessed with QUIPS tool
- Searches to 14 February 2025
Pooled result
As reported in the abstract
Long-term functional outcomes
- Poor neurological outcome, full cohort
- 78.9% (pooled proportion; 95% CI 73.5-83.4%; I2 = 95.6%)
- Poor neurological outcome, survivors (95% CI 5.8-16.3%; I2 86.4%); lower at longer follow-up
- 9.9%
- Clinically significant anxiety, survivors
- 13.1% (95% CI 6.1-26.0%; I2 = 92.3%)
- Clinically significant depression, survivors
- 8.1% (95% CI 4.6-13.7%; I2 = 75.7%)
- HRQoL impairment, pain/discomfort
- 60.5% (95% CI 57.9-63.0%; I2 = 37.6%)
- HRQoL impairment, usual activities
- 52.6% (95% CI 50.0-55.2%; I2 = 0.0%)
- HRQoL impairment, anxiety/depression
- 49.0% (95% CI 46.4-51.6%; I2 = 0.0%)
Original publication
Long-term functional outcomes and health-related quality of life following in-hospital cardiac arrest (IHCA): A systematic review. Resuscitation. Published 9 June 2025. doi:10.
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