Cardiac arrest & resuscitation
Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: an updated meta-analysis and trial sequential analysis
Pooled result · Overall in-hospital mortalityResult — go to the resultOdds ratio 0.63 95% CI 0.50–0.79Authors' conclusion
We found that ECPR reduces in-hospital mortality, improves neurological outcome, and 30-day survival.
Study context
- Population
- Patients with out-of-hospital cardiac arrest (OHCA) or in-hospital cardiac arrest (IHCA)13 studies · 14 pairwise comparisons
- Participants
- 6,336 vs 7,712
- Comparison
- Extracorporeal cardiopulmonary resuscitation (ECPR) vs conventional CPR
- ECPRn = 6,336
- Conventional CPR (CCPR)n = 7,712reference
- Outcome
- In-hospital mortality
Methodological detailsrandom-effects, trial sequential analysis, updated meta-analysis
- Random-effects
- Trial sequential analysis
- Updated meta-analysis
Pooled result
Overall in-hospital mortality
Odds ratio
0.63
95% CI 0.50–0.79
ECPR vs CCPR
OR 0.63 (95% CI 0.50–0.79)
As reported in the abstract
Further pooled results
In-hospital mortality, OHCA (subgroup)
- Newly significant decrease in mortality in OHCA with addition of recent studies
- OR 0.62, 95% CI 0.45-0.84
Short-term favourable neurological outcome and survival up to 30 days
- Re-analysis reaffirmed initial findings of favourable short-term neurological outcomes and survival up to 30 days
Long-term neurological outcome and 90-day-1-year survival
- Estimates remained unchanged
Original publication
Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: an updated meta-analysis and trial sequential analysis. Crit Care. Published 21 February 2024. doi:10.
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