Does the impact of peripheral nerve blocks vary by age and comorbidity subgroups? A nationwide population-based study
Authors' conclusion
PNB use is associated with beneficial effects more commonly observed among patients with a lower comorbidity burden, without a clear pattern of association with patient age.
Study context
- Population
- Patients undergoing total hip and knee arthroplasty, Premier Healthcare database (2006–2019), stratified by age and comorbidity subgroups
- Exposure
- Peripheral nerve blockade (PNB) use on the day of surgery vs no PNB
- Outcome
- Postoperative respiratory complications, acute renal failure, delirium, ICU admission, prolonged LOS and high opioid consumption across age and comorbidity subgroups
Methodological detailsnationwide population-based, mixed-effects models, subgroup analysis
- Nationwide population-based
- Mixed-effects models
- Subgroup analysis
Main finding
As reported in the abstract
Respiratory complications by subgroup (subgroup)
PNB vs No PNBOdds ratio (95% CI)
Subgroup as printed: adults and older adults with excellent or fair health (first of three ORs)
0.92(0.86–0.98)
Second of three ORs, same subgroup set
0.88(0.81–0.95)
Third of three ORs, same subgroup set
0.94(0.89–0.99)
Observational data: associations, not effects.
Original publication
Does the impact of peripheral nerve blocks vary by age and comorbidity subgroups? A nationwide population-based study. Reg Anesth Pain Med. Published 5 July 2023. doi:10.
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