Hemodynamics, fluids & transfusion
The dose-response relationship between norepinephrine dose and mean arterial pressure with and without general anaesthesia: A study in healthy volunteers
Authors' conclusion
Linear models accurately described norepinephrine dose-response relationships in healthy volunteers in a simulated surgical environment, with a steeper slope observed during general anaesthesia.
Study context
- Population
- Healthy volunteers aged 18 to 70 years, tertiary university medical centre
- Participants
- 36 volunteers
- Exposure
- Norepinephrine dose-MAP relationship awake vs under general anaesthesia
- Outcome
- Dose-response relationship between norepinephrine dose or plasma concentration and MAP
Methodological detailscrossover awake vs general anaesthesia, simulated surgical stimuli
- Crossover awake vs general anaesthesia
- Simulated surgical stimuli
Main finding
As reported in the abstract
Dose-MAP relationship (slope)
Slope increase
119 mmHg μg −1 kg min
95% CI 119–120P < 0.001
P for difference in slopes and intercepts
Mean arterial pressure (MAP) decrease after induction
34 mmHg
95% CI −37 to −31
from 88 mmHg (95% CI: 85 to 91)
Awake
103
slope · 95% CI 81–124 · mmHg μg −1 kg min
- Cumulative slope during anaesthesia approximately
- 222 mmHg μg −1 kg min
Observational data: associations, not effects.
Original publication
The dose-response relationship between norepinephrine dose and mean arterial pressure with and without general anaesthesia: A study in healthy volunteers. Eur J Anaesthesiol. Published 20 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →