Cardiac arrest & resuscitation
Drug therapy versus placebo or usual care for comatose survivors of cardiac arrest; a systematic review with meta-analysis
Authors' conclusion
In comatose survivors of cardiac arrest, the majority of trials of drug therapy reported no effect on mortality. Meta-analyses of steroids, coenzyme Q10 and thiamine demonstrated no evidence of an effect on mortality.
Study context
- Population
- Comatose survivors of cardiac arrest
- Participants
- 5,800 survivors · 45 studies
- Comparison
- Drug therapy vs placebo or usual care
- Outcome
- Mortality
- Follow-up
- 30 days/hospital discharge
Methodological detailsRisk of bias assessed using Cochrane Risk-Of-Bias Version 1, Last searched 20th October 2024
- Risk of bias assessed using Cochrane Risk-Of-Bias Version 1
- Last searched 20th October 2024
Pooled result
As reported in the abstract
Each group vs placebo or usual careRelative risk (95 % CI)P value
Steroidsn = 739; I2 = 60 %, low certainty
0.93(0.83–1.04)
P = 0.21Coenzyme Q10n = 107; I2 = 0 %, low certainty
0.91(0.61–1.37)
P = 0.65Thiaminen = 149; I2 = 0 %, very low certainty
1.11(0.88–1.40)
P = 0.39Original publication
Drug therapy versus placebo or usual care for comatose survivors of cardiac arrest; a systematic review with meta-analysis. Resuscitation. Published 14 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →