Cardiac arrest & resuscitation
Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial
Authors' conclusion
In out-of-hospital cardiac arrest patients, intravenous vitamin C did not reduce organ dysfunction at 96 h, but even worsened organ function outcomes in the 10 g group.
Study context
- Population
- Comatose adults resuscitated from shockable OHCAincluded in primary analysis
- Participants
- 273 adults
- Comparison
- IV vitamin C 3 g or 10 g daily for 96 h vs placebo
- Placebon = 93reference
- 3 gn = 91
- 10 gn = 89
- Primary endpoint
- Change in resuscitation-sequential organ failure assessment (R-SOFA) score
- Follow-up
- 96 h
Methodological detailsdouble-blind, multicentre, phase 2, placebo-controlled
- Double-blind
- Multicentre
- Phase 2
- Placebo-controlled
Primary result
As reported in the abstract
Change in R-SOFA score
Placebo
- 3.2
mean · SD 5.7
3 g
- 2.3
mean · SD 7.4
10 g
- 0.8
mean · SD 7.6
Difference, points (95% CI)P value
10 g vs Placebo
2.5(0.5–4.5)
P = 0.0110 g vs 3 g
1.6(- 0.4 to 3.6)
P = 0.12Safety
- Vitamin C 10 g led to higher troponin T release, worse renal function and worse neurological outcomes
Original publication
Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial. Intensive Care Med. Published 16 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →