Cardiac arrest & resuscitation
Thiamine as a metabolic resuscitator after out-of-hospital cardiac arrest
- terminated early
- Stopped early on DSMB recommendation after subgroup mortality difference
Authors' conclusion
In this single-center randomized trial, thiamine did not affect lactate over 24 hours after OHCA.
Study context
- Population
- Comatose adults within 4.5 h of ROSC after out-of-hospital cardiac arrest (OHCA) with lactate ≥ 3 mmol/L76 enrolled and analysed
- Participants
- 93 adults
- Comparison
- Thiamine vs placebo
- Primary endpoint
- Lactate (baseline, 6, 12 and 24 h; linear mixed model)
- Follow-up
- 24 hours
Methodological detailssingle-centre, blinded, placebo-controlled, Phase II, stratified by lactate >5 or ≤5 mmol/L
- Single-centre
- Blinded
- Placebo-controlled
- Phase II
- Stratified by lactate >5 or ≤5 mmol/L
Primary result
As reported in the abstract
Lactate over 24 h
No difference in lactate over 24 h: mean difference (95% CI −1.82, 2.50), p = 0.43
0.34 mmol/L
Secondary outcomes
Mortality, by randomisation lactate subgroup
- Mortality higher with thiamine in lactate > 5 mmol/L subgroup and lower in < 5 mmol/L subgroup
- Interaction p = 0.01
- Prompted DSMB to recommend early termination
PDH activity · 72 hours
- PDH activity increased over 72 h with thiamine
SOFA score, renal injury, neurological outcome, other secondary outcomes
- No differences in other secondary outcomes
Original publication
Thiamine as a metabolic resuscitator after out-of-hospital cardiac arrest. Resuscitation. Published 28 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →