Cardiac arrest & resuscitation
Potassium disorders at intensive care unit admission and functional outcomes after cardiac arrest
Authors' conclusion
Hyperkalaemia was associated with unfavourable functional outcomes at 180 days, while hypokalaemia was not.
Study context
- Population
- Comatose patients admitted to intensive care unit (ICU) after return of spontaneous circulation (ROSC) following cardiac arrest (HYPERION, TTH48, COMACARE, Xe-HYPOTHECA trials)
- Participants
- 1,133 patients · 4 RCTs
- Comparison
- Hyperkalaemia or hypokalaemia vs normokalaemia at ICU admission
- Normokalaemian = 877reference
- Hypokalaemian = 35
- Hyperkalaemian = 221
- Primary endpoint
- Unfavourable functional outcome (cerebral performance category 3 to 5)
- Follow-up
- 180 days
Methodological detailsmixed effects logistic regression
- Mixed effects logistic regression
Primary result
As reported in the abstract
Unfavourable functional outcome
Each group vs normokalaemiaEstimate (95 % CI)P value
Hyperkalaemia
aOR 1.85(1.10–3.12)
P = 0.02Hypokalaemia
OR 1.36(0.51–3.60)
P = 0.53Further findings
| Outcome | OR (95 % CI) | P value | |
|---|---|---|---|
| Unfavourable functional outcome, adjusted for modified cardiac arrest hospital prognosis score (subgroup, 833 patients)Hyperkalaemia vs Normokalaemia · not significant | 1.74 (0.91–3.34) | P = 0.10 | |
| Unfavourable functional outcome, adjusted for modified cardiac arrest hospital prognosis score (subgroup, 833 patients)Hypokalaemia vs Normokalaemia · not significant | 1.48 (0.40–5.44) | P = 0.55 | |
| 0.20.5125Odds ratio (log scale) |
%
| Outcome | Hypokalaemia | Hyperkalaemia |
|---|---|---|
| Prevalence of potassium disorders at ICU admission | 3.1 | 19.5 |
Original publication
Potassium disorders at intensive care unit admission and functional outcomes after cardiac arrest. Resuscitation. Published 20 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →