Cardiac arrest & resuscitation
Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials
Primary result · CPC 1 or 2 at 6 monthsResult — go to the resultAdjusted odds ratio 0.45 95% CI 0.26–0.79Authors' conclusion
Early hyponatremia was common in patients with ROSC after cardiac arrest and was associated with a poorer 6-month functional outcome.
Study context
- Population
- Post-cardiac-arrest patients admitted to the ICU with coma after stable return of spontaneous circulation (ROSC)
- Participants
- 1,163 patients · 4 RCTs
- Comparison
- Hyponatremia or hypernatremia vs normal natremia at ICU admission
- Normaln = 893reference
- Hyponatremian = 211
- Hypernatremian = 31
- Primary endpoint
- Cerebral Performance Category (CPC) 1 or 2
- Follow-up
- 6 months
Methodological detailsindividual patient data pooled, mCAHP-adjusted
- Individual patient data pooled
- mCAHP-adjusted
Primary result
CPC 1 or 2 at 6 months
Adjusted odds ratio
0.45
95% CI 0.26–0.79
P = 0.005
Events by treatment group
Hyponatremia vs Normal
aOR 0.45 (95% CI 0.26–0.79); P = 0.005
As reported in the abstract
Further findings
- Mean natremia on ICU admission (mmol/L), mean ± SD
- 137.5 ± 4.7
Original publication
Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials. Crit Care. Published 1 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →