ICU sedation, delirium & recovery
Early and late effects of volatile sedation with sevoflurane on respiratory mechanics of critically ill COPD patients
Authors' conclusion
In critically ill patients intubated with COPD exacerbation, there was no significant difference in respiratory mechanics between sevoflurane and propofol from inclusion to H4 and H48.
Study context
- Population
- Critically ill intubated patients with severe COPD exacerbation
- Participants
- 16 participants
- Comparison
- Sevoflurane vs propofol sedation
- Primary endpoint
- Total airway resistance change from baseline
- Follow-up
- H48
Methodological detailsprospective, single ICU
- Prospective
- Single ICU
Primary result
As reported in the abstract
Airway resistance and respiratory mechanics · H4 and H48
- No significant early (H4) or late (H48) difference in airway resistance and respiratory mechanics between groups
Further findings
Duration of sedation
Baseline airway resistance
P = 0.73
Baseline trapped volume
P = 0.02
Intrinsic PEEP after external PEEP optimization
- 1.5 cmH2O (1-3) in both groups
Original publication
Early and late effects of volatile sedation with sevoflurane on respiratory mechanics of critically ill COPD patients. Ann Intensive Care. Published 18 June 2024. doi:10.
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