Respiratory failure & ventilation
Inhaled sedation versus intravenous sedation in ARDS: A systematic review and meta-analysis
Authors' conclusion
Inhaled sedation was associated with similar mortality and ventilation duration compared with intravenous sedation, while showing a shorter ICU stay and improved oxygenation. However, it is associated with a higher risk of AKI.
Study context
- Population
- Adults (≥18 years) with ARDS undergoing invasive mechanical ventilation
- Participants
- 1,440 adults · 8 studies
- Comparison
- Inhaled sedation vs intravenous (IV) sedation
Methodological detailsfixed- or random-effects models
- Fixed- or random-effects models
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| Short-term mortality | 1.20 (0.94–1.55) | |
| 0.512Odds ratio (log scale) |
| Outcome | MD (days) (95% CI) | |
|---|---|---|
| Duration of mechanical ventilation | −0.35 (−4.01 to 3.32) | |
| ICU LOS | −2.27 (−3.75 to −0.80) | |
| −6−4−2024Difference, days (linear scale) |
| Outcome | MD (mmHg) (95% CI) | |
|---|---|---|
| PaO2/FiO2Improved · analyses driven by sevoflurane-containing studies | 39.7 (10.44–68.95) | |
| −50050100Difference, mmHg (linear scale) |
Safety
Acute kidney injury (AKI)
| OR (95% CI) | ||
|---|---|---|
| Sevoflurane | 1.68 (1.25–2.24) | |
| 0.512Odds ratio (log scale) |
Original publication
Inhaled sedation versus intravenous sedation in ARDS: A systematic review and meta-analysis. J Clin Anesth. Published 10 April 2026. doi:10.
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