Neuroanesthesia & neurocritical care
Early Cold-stored Platelet Transfusion following Traumatic Brain Injury: A Randomized Clinical Trial
Primary result · 6-month Glasgow Outcome Scale-extended score distributionResult — go to the resultOdds ratio 1.58 95% CI 0.71–3.54Authors' conclusion
In brain-injured patients requiring platelet transfusion, early CSP transfusion is feasible and did not result in improved 6-month Glasgow Coma Scale-extended scores. Early CSP transfusion was associated with a lower rate of neurosurgical operative intervention without an increase in adverse events. The storage age of the CSP product was not associated with outcome differences.
Study context
- Population
- Traumatic brain injury (TBI) patients with positive brain imaging needing platelet transfusion, single US trauma center
- Comparison
- Cold-stored platelets vs standard care room temperature (RT) platelet transfusion
- Primary endpoint
- Feasibility; principal clinical outcome for efficacy and safety: Glasgow Outcome Scale-extended score
- Follow-up
- 6 months
Methodological detailsphase 2, open-label, single-centre
- Phase 2
- Open-label
- Single-centre
Primary result
As reported in the abstract
6-month Glasgow Outcome Scale-extended score distribution
Odds ratio
1.58
95% CI 0.71–3.54
P = 0.27
CSP vs RT
OR 1.58 (95% CI 0.71–3.54); P = 0.27
Further findings
| Outcome | Difference (95% CI) | P value | |
|---|---|---|---|
| Neurosurgical craniotomy/craniectomy | −14.4% (−26.5% to −2.3%) | P = 0.03 | |
| −40−20020Difference (linear scale) |
Storage age of cold-stored product
- Not associated with outcome differences
Safety
- Adverse event rates did not differ across groups
Original publication
Early Cold-stored Platelet Transfusion following Traumatic Brain Injury: A Randomized Clinical Trial. Ann Surg. Published 22 January 2025. doi:10.
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