ICU sedation, delirium & recovery
Early Deep Sedation Practices Worsened During the Pandemic Among Adult Patients Without COVID-19: A Retrospective Cohort Study
Authors' conclusion
We found that among patients on mechanical ventilation without COVID-19, sedation use increased during the pandemic.
Study context
- Population
- Adults intubated without COVID-19
- Participants
- 4,237 adults
- Exposure
- Pandemic and late pandemic vs prepandemic periods
- Outcome
- Time deeply sedated
- Follow-up
- First 48 h after intubation
Methodological detailselectronic health record data
- Electronic health record data
Main finding
As reported in the abstract
Hours deeply sedated in first 48 h
Prepandemic
13.0
average · h
Each group vs prepandemicIncrease, h (95% CI)
Pandemic
1.9(1.0–2.8)
Late pandemic
2.9(2.0–3.8)
Observational data: associations, not effects.
Further findings
Deeply sedated over one-half of first 48 h
| Outcome | Estimate | |
|---|---|---|
| Alive without mechanical ventilation (ventilator-free days) · 28 daysPandemic vs Prepandemic | subdistribution HR 0.87 (95% CI 0.79–0.95) | |
| Tracheostomy placementPandemic vs Prepandemic | OR 1.41 (95% CI 1.08–1.82) | |
| 0.512Ratio (log scale) |
| Outcome | Increase (h) (95% CI) | |
|---|---|---|
| Hours deeply sedated in first 48 h (medical ICU subgroup)Pandemic vs Prepandemic | 2.5 (0.6–4.4) | |
| Hours deeply sedated in first 48 h (medical ICU subgroup)Late pandemic vs Prepandemic | 4.9 (3.0–6.9) | |
| −50510Difference, h (linear scale) |
Original publication
Early Deep Sedation Practices Worsened During the Pandemic Among Adult Patients Without COVID-19: A Retrospective Cohort Study. Chest. Published 12 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →