ICU sedation, delirium & recovery
Early deep-to-light sedation versus continuous light sedation for intensive care unit (ICU) patients with mechanical ventilation: A cohort study
Authors' conclusion
Compared to the continuous light sedation, early deep-to-light sedation strategy was associated with improved patient outcomes, and continuous deep sedation was confirmed with poorer patient outcomes.
Study context
- Population
- ICU patients receiving invasive mechanical ventilation (MV) for more than 3 days with one of three sedation strategies (ICU-HAI, China; Medical Information Mart for Intensive Care (MIMIC))2,627 ICU-HAI, 4073 MIMIC
- Participants
- 6,700 patients
- Exposure
- Early deep-to-light sedation or continuous deep sedation vs continuous light sedation
- Continuous light sedation (CLS)n = 2,689reference
- Continuous deep sedation (CDS)n = 2,079
- Deep-to-light sedation (DTLS)n = 1,932
- Outcome
- Ventilator, ICU or hospital mortality
Methodological detailstwo ICU databases (ICU-HAI, MIMIC), inverse probability-weighted competing risk models, fixed-effects pooling
- Two ICU databases (ICU-HAI, MIMIC)
- Inverse probability-weighted competing risk models
- Fixed-effects pooling
Main finding
As reported in the abstract
ICU mortality
Each group vs CLSPooled adjusted hazard ratio (95% CI)
DTLS
0.78(0.66–0.94)
CDS
3.39(2.95–3.90)
Observational data: associations, not effects.
Further findings
| Outcome | CLS | CDS | DTLS | Pooled adjusted HR (CI) | |
|---|---|---|---|---|---|
| Hospital mortalityDTLS vs CLS | 14.1% | 46.8% | 16.0% | 0.86 (0.74–1.00) | |
| Hospital mortalityCDS vs CLS | 3.27 (2.89–3.71) | ||||
| Ventilator mortalityCDS vs CLS | 7.0% | 32.8% | — not stated in the abstract | 4.65 (3.91–5.53) | |
| 0.20.5125Pooled adjusted hazard ratio (log scale) |
— not stated in the abstract
Original publication
Early deep-to-light sedation versus continuous light sedation for ICU patients with mechanical ventilation: A cohort study. Anaesth Crit Care Pain Med. Published 11 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →