Cardiac arrest & resuscitation
Early Extracorporeal Cardiopulmonary Resuscitation (CPR) for Refractory Out-of-Hospital Cardiac Arrest
Primary result · Survival with favourable neurologic outcome (Cerebral Performance Category 1 or 2)Result — go to the resultOR for survival with favourable neurologic outcome 1.4 95% CI 0.5–3.5Authors' conclusion
In patients with refractory out-of-hospital cardiac arrest, extracorporeal CPR and conventional CPR had similar effects on survival with a favorable neurologic outcome.
Study context
- Population
- Adults 18–70 y with refractory OHCA, bystander CPR, initial ventricular arrhythmia, no ROSC within 15 min of CPR; Netherlands26 excluded after randomisation
- Participants
- 160 adults
- Comparison
- ECPR vs conventional CPR
- Extracorporeal CPRn = 70
- Conventional CPRn = 64reference
- Primary endpoint
- Survival with favourable neurologic outcome (Cerebral Performance Category 1 or 2)
- Follow-up
- 30 days
Methodological detailsmulticentre, intention-to-treat
- Multicentre
- Intention-to-treat
Primary result
As reported in the abstract
OR for survival with favourable neurologic outcome
1.4
95% CI 0.5–3.5
P = 0.52
Events by treatment group
Extracorporeal CPR vs Conventional CPR
OR for survival with favourable neurologic outcome 1.4 (95% CI 0.5–3.5); P = 0.52
Safety
Serious adverse events per patient
- Similar in the two groups
Original publication
Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest. N Engl J Med. Published 26 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →