Respiratory failure & ventilation
Early hyperbaric oxygen therapy is associated with favorable outcome in patients with iatrogenic cerebral arterial gas embolism: systematic review and individual patient data meta-analysis of observational studies
Pooled result · Difference in median time-to-HBOT (group level)Result — go to the resultDifference 2.4 h 95% CI 0.6–9.7Authors' conclusion
Increased time-to-HBOT is associated with decreased probability of favorable outcome in iatrogenic CAGE.
Study context
- Population
- Patients with iatrogenic cerebral arterial gas embolism (CAGE) caused by invasive medical procedures, treated with hyperbaric oxygen therapy (HBOT)
- Participants
- 263 patients · 10 studies
- Comparison
- Time-to-HBOT in patients with favorable vs unfavorable outcome
- Outcome
- Relationship between time-to-HBOT and favorable outcome
Methodological detailsgroup level and individual patient level meta-analysis, generalized linear mixed effects model
- Group level and individual patient level meta-analysis
- Generalized linear mixed effects model
Pooled result
Difference in median time-to-HBOT (group level)
Difference
2.4 h
95% CI 0.6–9.7
Favorable outcome vs Unfavorable outcome
difference 2.4 h (95% CI 0.6–9.7)
As reported in the abstract
Further pooled results
Time-to-HBOT and probability of favorable outcome (individual patient level, 8 studies, 126 patients)
- Significant relationship between time-to-HBOT and probability of favorable outcome
- P = 0.013
- Remains significant after correcting for severity of manifestations
- P = 0.041
- Probability of favorable outcome, HBOT started immediately
- ≈65%
- Probability of favorable outcome, HBOT delayed for 15 h
- 30%
- Generalized linear mixed effects model
Original publication
Early hyperbaric oxygen therapy is associated with favorable outcome in patients with iatrogenic cerebral arterial gas embolism: systematic review and individual patient data meta-analysis of observational studies. Crit Care. Published 12 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →